Anti-Vaccine Topics
SARS-CoV-2 vaccine and concerns for fertility.

SARS-CoV-2 vaccine and concerns for fertility.

SARS-CoV-2 (the virus causing COVID-19) is a beta-CoV (beta coronavirus)(1) sharing similarities with the original SARS (SARS-CoV), MERS (MERS-CoV), murine coronavirus mouse hepatitis virus (MHV-A39), two of the seasonal coronavirus (Hong Kong SARS (HKU-SARS(2) and HCoV-OC43), and a few bat coronavirus.

All Coronaviruses have similar structures, which include distinguishing spike proteins (commonly called Protein S), which are foci which allow the virus to target receptors and bind to the cell. These spike proteins give coronaviruses a crown like appearance under electron microscopy.

MERS-CoV was shown to bind with certain cellular proteases which cleave the protein spike and allow it to bind with the cellular wall. The MHV-A39 Murine CoV as well as the HKU-SARS (HCoV-HKU1) viruses also bind to similar target proteases. Both SARS-CoV and SARS-CoV-2 (3) target Angiotensin Converting Enzyme 2 (ACE2) receptors, which are common receptors in the lungs and other vascular organs. While there are a small number of variants to Protein S (the spike protein), the target of the spike protein doesn’t change, only the level of interaction between the ACE2 receptor. This is hypothesized to be contributing to the infectiousness of the virus (3).

Even with these slight variations to the spike protein, it’s unlikely these variations will impact the immunity developed by immunizations/vaccinations, as the target receptor isn’t changing.

In a post seeing fairly wide distribution, the author of the graphic states that the new SARS-CoV-2 vaccines “contains a spike protein called sincytin-1…” This is blatantly false, as we have already discussed, the spike protein of the CoVs are called Protein S (to delineate them from three other viral proteins [Protein E, Protein M, and Protein N), with each of the protein letters delineating the location of the protein {E = envelope, M = membrane, and N = nucleocapsid}).

This is a deliberate attempt to undermine confidence in the SARS-CoV-2 vaccines, as any reader which would search for “sincytin-1” will find that this is a retroviral protein used by the placenta to bind to the uterine wall (4).

The author then continues to use this misinformation to imply that the (alleged) presence of sincytin-1 in the vaccine will interfere with an individual’s future possibility of becoming pregnant.

This is both incredibly false and also disturbing that anyone would think that deliberately lying about this is ethical or moral, no matter what the reason is for their justification.

The entire premise of this disinformation is based on a false assumption that the COVID-19 vaccine has a spike protein sincytin-1, and that the spike protein of the SARS-CoV-2 (or any of the other coronaviruses for that matter) are sincytin-1. If this even had a shred of credibility, than any of the CoVs native infections would/could cause infertility, including the common cold.

Since the spike proteins aren’t in any way similar to sincytin-1, the assumptions and conclusions of the original post are completely false.


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