mRNA Vaccines
mRNA: Can it alter the DNA of your cell?

mRNA: Can it alter the DNA of your cell?

The simple answer is no.

For further explanation of why this is realistically not possible, please read below….

So let’s talk about what DNA and RNA is first. DNA/RNA are both sugar/phosphate based chains which have a series of “segments” (nucleotides), made of four different “tips” (called nucleobases), arranged in groups of three (called codons). The average human DNA contains 3 billion base pairs, so there is availability for around 1 billion codons. DNA is most secure when it is in its double helix shape (when both strands of DNA’s bases pair, and the strands twist to help keep them secure. RNA always (not aware of any exceptions to this rule) exist as single strands.

With RNA, the sugar phosphate backbone is composed of Ribose, and with DNA, the sugar phosphate backbone is composed of deoxyribose.

The deoxyribose/phosphate bind gives DNA a higher strength (allowing it to form a double helix shape) and durability (able to be unzipped and zipped back up multiple times), when compared to RNA. This is important because DNA is designed to keep long term genetic material, while RNA is designed to be used temporarily and discarded.

See image for an illustration of RNA/DNA and their shapes.

(image: Sponk, Creative Commons 3.0)

There is also significant differences between DNA and RNA. DNA is the permanent genetic material which resides in the nucleus (the command center) of the cell. DNA encodes the genetic material necessary to provide cellular function, how to replicate, and when cells should die. DNA exists in what’s called a double helix (a two stranded, circular twisting pattern) which is extremely stable, thus limiting genetic changes. RNA is a temporary copy of DNA, allowing the cell to transfer the information contained in the DNA outside of the nucleus (the “command center”) to where the cell creates the structures necessary for cellular life. RNA is a single-strand structure, which can allow for genetic damage/changes to occur easier than DNA, but due to the temporary nature of RNA, these genetic changes are temporary.

I’ve often heard anti-vaccine advocates repeat the false notion that DNA/RNA outside of a cell can cause changes to a cells DNA. This is demonstrably false. Dr Deischer frequently makes these claims, yet even the literature she cites to “support” her erroneous claims state that it is pretty much impossible for this to occurs without very specific adaptations to allow the DNA/RNA to first cross the nuclear membrane, let alone insert itself into the cells DNA. Dr Deischer frequently cites the literature which documents technology behind CRISPR (the gene editing technology), but takes this research to claim that the body can do this independently of scientific assistance, despite mountains of evidence which refute her claims.

The reason why this is impossible without scientific assistance is largely due to two reasons.

1. Enzymes outside of the cell quickly denature and destroy DNA/RNA.

2. Even when DNA/RNA is able to enter the cell through diffusion, it has three distinct problems, depending on whether it is a single strand DNA, Double strand DNA, or RNA:

A. Single strand DNA isn’t able to directly be translated to create proteins without first translating it into RNA. These mechanisms exist Solely in the nucleus of the cell, so these DNA fragments are not usable, unable to enter the nucleus without help, let alone insert itself into the genome without the instructions to do so.

B. Double strand DNA has the same difficulties as single stranded DNA, in addition it requires the mechanism to unzip and zip the DNA strand prior to translation into RNA. Again, these mechanisms exist within the nucleus of the cell only, which leaves them inactive and likely destroyed by cellular function to be reused,

C. RNA viruses require the same mechanisms to enter the cell nucleus, and insert themselves into the genome, AND they require a reverse transcriptase (an enzyme which constructs DNA from RNA), which isn’t present in cells without the presence of a retrovirus.

So with the research behind gene editing, we have learned that to allow enough DNA/RNA through the cell wall, we need to use a buffer of lipids to block the enzymes outside of the cell from breaking down the mRNA. Just note, that even though this genetic material is able to gain access to the cell, this doesn’t give access to the nucleus (where the cells DNA is stored).

This is why the current mRNA vaccines have one or two lipid components, to prevent degradation outside of the cell. Once the mRNA is within the cell, the cells structures will take the mRNA and create proteins based on the genetic material in the mRNA. These proteins have immune receptor sites on them, which mark them as a foreign substance, which initiates the immune stimulation process, activating the innate and adaptive immune systems. This activation is what produces the immunities to the specific spike protein.

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